Rapid Disruption of Axon-Glial Integrity in Response to Mild Cerebral Hypoperfusion

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Rapid disruption of axon-glial integrity in response to mild cerebral hypoperfusion.

Myelinated axons have a distinct protein architecture essential for action potential propagation, neuronal communication, and maintaining cognitive function. Damage to myelinated axons, associated with cerebral hypoperfusion, contributes to age-related cognitive decline. We sought to determine early alterations in the protein architecture of myelinated axons and potential mechanisms after hypop...

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Chronic cerebral hypoperfusion is a key mechanism associated with white matter disruption in cerebral vascular disease and dementia. In a mouse model relevant to studying cerebral vascular disease, we have previously shown that cerebral hypoperfusion disrupts axon-glial integrity and the distribution of key paranodal and internodal proteins in subcortical myelinated axons. This disruption of my...

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ژورنال

عنوان ژورنال: Journal of Neuroscience

سال: 2011

ISSN: 0270-6474,1529-2401

DOI: 10.1523/jneurosci.4936-11.2011